DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation

A minority of cancers have breast cancer gene (BRCA) mutations that confer sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis), but the role for PARPis in BRCA-proficient cancers is not well established. This suggests the need for novel combination therapies to expand the use of t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Abbotts, Rachel, Topper, Michael J., Biondi, Christopher, Fontaine, Daniel, Goswami, Reena, Stojanovic, Lora, Choi, Eun Yong, McLaughlin, Lena, Kogan, Aksinija A., Xia, Limin, Lapidus, Rena, Mahmood, Javed, Baylin, Stephen B., Rassool, Feyruz V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842607/
https://ncbi.nlm.nih.gov/pubmed/31591209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903765116
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