DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation

A minority of cancers have breast cancer gene (BRCA) mutations that confer sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis), but the role for PARPis in BRCA-proficient cancers is not well established. This suggests the need for novel combination therapies to expand the use of t...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Abbotts, Rachel, Topper, Michael J., Biondi, Christopher, Fontaine, Daniel, Goswami, Reena, Stojanovic, Lora, Choi, Eun Yong, McLaughlin, Lena, Kogan, Aksinija A., Xia, Limin, Lapidus, Rena, Mahmood, Javed, Baylin, Stephen B., Rassool, Feyruz V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842607/
https://ncbi.nlm.nih.gov/pubmed/31591209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903765116
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