Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors

Chromosomal instability is a defining feature of clonal myeloma plasma cells that results in the perpetual accumulation of genomic aberrations. In addition to its role in protein homeostasis, the ubiquitin-proteasome system is also involved in the regulation of DNA damage-repair proteins. In the pre...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Neri, Paola, Ren, Li, Gratton, Kathy, Stebner, Erin, Johnson, Jordan, Klimowicz, Alexander, Duggan, Peter, Tassone, Pierfrancesco, Mansoor, Adnan, Stewart, Douglas A., Lonial, Sagar, Boise, Lawrence H., Bahlis, Nizar J.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348156/
https://ncbi.nlm.nih.gov/pubmed/21917757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-363911
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