Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation

Proteasome inhibitors such as bortezomib are highly active in multiple myeloma by affecting signaling cascades and leading to a toxic buildup of misfolded proteins. Bortezomib-treated cells activate the cytoprotective heat shock response (HSR), including upregulation of heat shock proteins (HSPs). H...

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Udgivet i:Oncotarget
Main Authors: Shah, Shardule P., Nooka, Ajay K., Jaye, David L., Bahlis, Nizar J., Lonial, Sagar, Boise, Lawrence H.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312344/
https://ncbi.nlm.nih.gov/pubmed/27487129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10847
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