DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

BACKGROUND: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of the encoding gene (IDO1) in HNSCC. METHODS: Methyl...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:EBioMedicine
Asıl Yazarlar: Sailer, Verena, Sailer, Ulrike, Bawden, Emma Grace, Zarbl, Romina, Wiek, Constanze, Vogt, Timo J., Dietrich, Joern, Loick, Sophia, Grünwald, Ingela, Toma, Marieta, Golletz, Carsten, Gerstner, Andreas, Kristiansen, Glen, Bootz, Friedrich, Scheckenbach, Kathrin, Landsberg, Jennifer, Dietrich, Dimo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2019
Konular:
Research paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838413/
https://ncbi.nlm.nih.gov/pubmed/31628024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.038
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