LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma

BACKGROUND: Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for immune checkpoint inhibition in clear cell renal cell carcinoma (KIRC). The aim of this study was to investigate the epigenetic regulation of LAG3 in KIRC by methylation. METHODS: We correlated quantitative LAG3 methy...

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Dettagli Bibliografici
Pubblicato in:J Immunother Cancer
Autori principali: Klümper, Niklas, Ralser, Damian J, Bawden, Emma Grace, Landsberg, Jenny, Zarbl, Romina, Kristiansen, Glen, Toma, Marieta, Ritter, Manuel, Hölzel, Michael, Ellinger, Jörg, Dietrich, Dimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2020
Soggetti:
Immunotherapy Biomarkers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174079/
https://ncbi.nlm.nih.gov/pubmed/32234847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000552
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