LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma

BACKGROUND: Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for immune checkpoint inhibition in clear cell renal cell carcinoma (KIRC). The aim of this study was to investigate the epigenetic regulation of LAG3 in KIRC by methylation. METHODS: We correlated quantitative LAG3 methy...

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Библиографические подробности
Опубликовано в: :J Immunother Cancer
Главные авторы: Klümper, Niklas, Ralser, Damian J, Bawden, Emma Grace, Landsberg, Jenny, Zarbl, Romina, Kristiansen, Glen, Toma, Marieta, Ritter, Manuel, Hölzel, Michael, Ellinger, Jörg, Dietrich, Dimo
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2020
Предметы:
Immunotherapy Biomarkers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174079/
https://ncbi.nlm.nih.gov/pubmed/32234847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000552
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