Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma

BACKGROUND: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in melanoma and its microenvironment. METHODS: We eval...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Fröhlich, Anne, Sirokay, Judith, Fietz, Simon, Vogt, Timo J., Dietrich, Jörn, Zarbl, Romina, Florin, Mike, Kuster, Pia, Saavedra, Gonzalo, Valladolid, Susana Ramírez, Hoffmann, Friederike, Flatz, Lukas, Ring, Sandra S., Golletz, Carsten, Pietsch, Torsten, Strieth, Sebastian, Brossart, Peter, Gielen, Gerrit H., Kristiansen, Glen, Bootz, Friedrich, Landsberg, Jennifer, Dietrich, Dimo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7475111/
https://ncbi.nlm.nih.gov/pubmed/32861198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102962
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