Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma

BACKGROUND: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in melanoma and its microenvironment. METHODS: We eval...

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Pubblicato in:EBioMedicine
Autori principali: Fröhlich, Anne, Sirokay, Judith, Fietz, Simon, Vogt, Timo J., Dietrich, Jörn, Zarbl, Romina, Florin, Mike, Kuster, Pia, Saavedra, Gonzalo, Valladolid, Susana Ramírez, Hoffmann, Friederike, Flatz, Lukas, Ring, Sandra S., Golletz, Carsten, Pietsch, Torsten, Strieth, Sebastian, Brossart, Peter, Gielen, Gerrit H., Kristiansen, Glen, Bootz, Friedrich, Landsberg, Jennifer, Dietrich, Dimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7475111/
https://ncbi.nlm.nih.gov/pubmed/32861198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102962
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