Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma

BACKGROUND: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in melanoma and its microenvironment. METHODS: We eval...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EBioMedicine
Main Authors: Fröhlich, Anne, Sirokay, Judith, Fietz, Simon, Vogt, Timo J., Dietrich, Jörn, Zarbl, Romina, Florin, Mike, Kuster, Pia, Saavedra, Gonzalo, Valladolid, Susana Ramírez, Hoffmann, Friederike, Flatz, Lukas, Ring, Sandra S., Golletz, Carsten, Pietsch, Torsten, Strieth, Sebastian, Brossart, Peter, Gielen, Gerrit H., Kristiansen, Glen, Bootz, Friedrich, Landsberg, Jennifer, Dietrich, Dimo
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Research paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7475111/
https://ncbi.nlm.nih.gov/pubmed/32861198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102962
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