DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

BACKGROUND: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of the encoding gene (IDO1) in HNSCC. METHODS: Methyl...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Sailer, Verena, Sailer, Ulrike, Bawden, Emma Grace, Zarbl, Romina, Wiek, Constanze, Vogt, Timo J., Dietrich, Joern, Loick, Sophia, Grünwald, Ingela, Toma, Marieta, Golletz, Carsten, Gerstner, Andreas, Kristiansen, Glen, Bootz, Friedrich, Scheckenbach, Kathrin, Landsberg, Jennifer, Dietrich, Dimo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838413/
https://ncbi.nlm.nih.gov/pubmed/31628024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.038
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