DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

BACKGROUND: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of the encoding gene (IDO1) in HNSCC. METHODS: Methyl...

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Publicat a:EBioMedicine
Autors principals: Sailer, Verena, Sailer, Ulrike, Bawden, Emma Grace, Zarbl, Romina, Wiek, Constanze, Vogt, Timo J., Dietrich, Joern, Loick, Sophia, Grünwald, Ingela, Toma, Marieta, Golletz, Carsten, Gerstner, Andreas, Kristiansen, Glen, Bootz, Friedrich, Scheckenbach, Kathrin, Landsberg, Jennifer, Dietrich, Dimo
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Research paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838413/
https://ncbi.nlm.nih.gov/pubmed/31628024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.038
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