Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In contrast, we demonstrate that inhibition of stromal TGFβR2 reduces IL‐6 pr...

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Publié dans:EMBO Mol Med
Auteurs principaux: Huang, Huocong, Zhang, Yuqing, Gallegos, Valerie, Sorrelle, Noah, Zaid, Mohamed Medhat, Toombs, Jason, Du, Wenting, Wright, Steven, Hagopian, Moriah, Wang, Zhaoning, Hosein, Abdel Nasser, Sathe, Adwait Amod, Xing, Chao, Koay, Eugene J, Driscoll, Kyla E, Brekken, Rolf A
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6835203/
https://ncbi.nlm.nih.gov/pubmed/31609088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910515
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