Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis

Elevated levels of TGF-β are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result the TGF-β pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGF-β remains challenging because TGF-β has tumor suppressor fun...

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Autori principali: Ostapoff, Katherine T., Cenik, Bercin Kutluk, Wang, Miao, Ye, Risheng, Xu, Xiaohong, Nugent, Desiree, Hagopian, Moriah M., Topalovski, Mary, Rivera, Lee B., Carroll, Kyla D., Brekken, Rolf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167492/
https://ncbi.nlm.nih.gov/pubmed/25060520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1807
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