The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized mutation...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO Mol Med
Päätekijät: Yan, Yuqian, Ma, Jian, Wang, Dejie, Lin, Dong, Pang, Xiaodong, Wang, Shangqian, Zhao, Yu, Shi, Lei, Xue, Hui, Pan, Yunqian, Zhang, Jun, Wahlestedt, Claes, Giles, Francis J, Chen, Yu, Gleave, Martin E, Collins, Collin C, Ye, Dingwei, Wang, Yuzhuo, Huang, Haojie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2019
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6835201/
https://ncbi.nlm.nih.gov/pubmed/31559706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910659
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