The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized mutation...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO Mol Med
Egile Nagusiak: Yan, Yuqian, Ma, Jian, Wang, Dejie, Lin, Dong, Pang, Xiaodong, Wang, Shangqian, Zhao, Yu, Shi, Lei, Xue, Hui, Pan, Yunqian, Zhang, Jun, Wahlestedt, Claes, Giles, Francis J, Chen, Yu, Gleave, Martin E, Collins, Collin C, Ye, Dingwei, Wang, Yuzhuo, Huang, Haojie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6835201/
https://ncbi.nlm.nih.gov/pubmed/31559706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910659
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