The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized mutation...

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Vydáno v:EMBO Mol Med
Hlavní autoři: Yan, Yuqian, Ma, Jian, Wang, Dejie, Lin, Dong, Pang, Xiaodong, Wang, Shangqian, Zhao, Yu, Shi, Lei, Xue, Hui, Pan, Yunqian, Zhang, Jun, Wahlestedt, Claes, Giles, Francis J, Chen, Yu, Gleave, Martin E, Collins, Collin C, Ye, Dingwei, Wang, Yuzhuo, Huang, Haojie
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6835201/
https://ncbi.nlm.nih.gov/pubmed/31559706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910659
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