Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate ca...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Yan, Yuqian, An, Jian, Yang, Yinhui, Wu, Di, Bai, Yang, Cao, William, Ma, Linlin, Chen, Junhui, Yu, Zhendong, He, Yundong, Jin, Xin, Pan, Yunqian, Ma, Tao, Wang, Shangqian, Hou, Xiaonan, Weroha, Saravut John, Karnes, R Jeffrey, Zhang, Jun, Westendorf, Jennifer J, Wang, Liguo, Chen, Yu, Xu, Wanhai, Zhu, Runzhi, Wang, Dejie, Huang, Haojie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887910/
https://ncbi.nlm.nih.gov/pubmed/29523594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708478
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