Loss of FOXO1 cooperates with TMPRSS2-ERG overexpression to promote prostate tumorigenesis and cell invasion

E26 transformation-specific (ETS) transcription factor ERG is aberrantly overexpressed in approximately 50% of all human PCa due to TMPRSS2-ERG gene rearrangements. However, mice with prostate-specific transgenic expression of PCa-associated ERG alone fail to develop PCa, highlighting that ERG requi...

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Publicat a:Cancer Res
Autors principals: Yang, Yinhui, Blee, Alexandra M., Wang, Dejie, An, Jian, Pan, Yunqian, Yan, Yuqian, Ma, Tao, He, Yundong, Dugdale, Joseph, Hou, Xiaonan, Zhang, Jun, Weroha, S. John, Zhu, Wei-Guo, Wang, Y. Alan, DePinho, Ronald A., Xu, Wanhai, Huang, Haojie
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712249/
https://ncbi.nlm.nih.gov/pubmed/28986382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0686
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