TMPRSS2-ERG controls luminal epithelial lineage and antiandrogen sensitivity in PTEN and TP53-mutated prostate cancer

PURPOSE: Deletions or mutations in PTEN and TP53 tumor suppressor genes have been linked to lineage plasticity in therapy-resistant prostate cancer. Fusion-driven overexpression of the oncogenic transcription factor ERG is observed in approximately 50% of all prostate cancers, many of which also har...

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Udgivet i:Clin Cancer Res
Main Authors: Blee, Alexandra M., He, Yundong, Yang, Yinhui, Ye, Zhenqing, Yan, Yuqian, Pan, Yunqian, Ma, Tao, Dugdale, Joseph, Kuehn, Emily, Kohli, Manish, Jimenez, Rafael, Chen, Yu, Xu, Wanhai, Wang, Liguo, Huang, Haojie
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139075/
https://ncbi.nlm.nih.gov/pubmed/29844131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0653
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