Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate ca...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Mol Med
Prif Awduron: Yan, Yuqian, An, Jian, Yang, Yinhui, Wu, Di, Bai, Yang, Cao, William, Ma, Linlin, Chen, Junhui, Yu, Zhendong, He, Yundong, Jin, Xin, Pan, Yunqian, Ma, Tao, Wang, Shangqian, Hou, Xiaonan, Weroha, Saravut John, Karnes, R Jeffrey, Zhang, Jun, Westendorf, Jennifer J, Wang, Liguo, Chen, Yu, Xu, Wanhai, Zhu, Runzhi, Wang, Dejie, Huang, Haojie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887910/
https://ncbi.nlm.nih.gov/pubmed/29523594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708478
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