Llwytho...
Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer
AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate ca...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | EMBO Mol Med |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
John Wiley and Sons Inc.
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5887910/ https://ncbi.nlm.nih.gov/pubmed/29523594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708478 |
| Tagiau: |
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