Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate ca...

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Dades bibliogràfiques
Publicat a:EMBO Mol Med
Autors principals: Yan, Yuqian, An, Jian, Yang, Yinhui, Wu, Di, Bai, Yang, Cao, William, Ma, Linlin, Chen, Junhui, Yu, Zhendong, He, Yundong, Jin, Xin, Pan, Yunqian, Ma, Tao, Wang, Shangqian, Hou, Xiaonan, Weroha, Saravut John, Karnes, R Jeffrey, Zhang, Jun, Westendorf, Jennifer J, Wang, Liguo, Chen, Yu, Xu, Wanhai, Zhu, Runzhi, Wang, Dejie, Huang, Haojie
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887910/
https://ncbi.nlm.nih.gov/pubmed/29523594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708478
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