ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

53BP1 activates nonhomologous end joining (NHEJ) and inhibits homologous recombination (HR) repair of DNA double-strand breaks (DSBs). Dissociation of 53BP1 from DSBs and consequent activation of HR, a less error-prone pathway than NHEJ, helps maintain genome integrity during DNA replication; howeve...

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Vydáno v:Sci Adv
Hlavní autoři: Wang, Dejie, Ma, Jian, Botuyan, Maria Victoria, Cui, Gaofeng, Yan, Yuqian, Ding, Donglin, Zhou, Yingke, Krueger, Eugene W., Pei, Jiang, Wu, Xiaosheng, Wang, Liguo, Pei, Huadong, McNiven, Mark A., Ye, Dingwei, Mer, Georges, Huang, Haojie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213225/
https://ncbi.nlm.nih.gov/pubmed/34144977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd9208
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