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DUB3 promotes BET inhibitor resistance and cancer progression through deubiquitinating BRD4
The bromodomain and extra-terminal domain (BET) protein BRD4 is emerging as a promising anticancer therapeutic target. However, resistance to BET inhibitors often occurs and it has been linked to aberrant degradation of BRD4 protein in cancer. Here, we demonstrate that the deubiquitinase DUB3 binds...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6086352/ https://ncbi.nlm.nih.gov/pubmed/30057199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.036 |
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