Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells i...

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Bibliografiska uppgifter
I publikationen:PLoS Pathog
Huvudupphovsmän: Pino, Maria, Paganini, Sara, Deleage, Claire, Padhan, Kartika, Harper, Justin L., King, Colin T., Micci, Luca, Cervasi, Barbara, Mudd, Joseph C., Gill, Kiran P., Jean, Sherrie M., Easley, Kirk, Silvestri, Guido, Estes, Jacob D., Petrovas, Constantinos, Lederman, Michael M., Paiardini, Mirko
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834281/
https://ncbi.nlm.nih.gov/pubmed/31626660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008081
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