CTLA-4(+)PD-1(−) memory CD4(+) T cells critically contribute to viral persistence in antiretroviral therapy-suppressed, SIV-infected rhesus macaques

Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals, but does not eliminate the reservoir of latently infected cells. Recent work identified PD-1(+) follicular helper T cells (Tfh) as an important cellular compartment for viral persistence. Here, using ART-treated,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: McGary, Colleen S., Deleage, Claire, Harper, Justin, Micci, Luca, Ribeiro, Susan P., Paganini, Sara, Kuri-Cervantes, Leticia, Benne, Clarisse, Ryan, Emily S., Balderas, Robert, Jean, Sherrie, Easley, Kirk, Marconi, Vincent, Silvestri, Guido, Estes, Jacob D., Sekaly, Rafick-Pierre, Paiardini, Mirko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679306/
https://ncbi.nlm.nih.gov/pubmed/29045906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.09.018
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