Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

Despite successful control of viremia, many HIV-infected individuals given antiretroviral therapy (ART) exhibit residual inflammation, which is associated with non–AIDS-related morbidity and mortality and may contribute to virus persistence during ART. Here, we investigated the effects of IL-21 admi...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Micci, Luca, Ryan, Emily S., Fromentin, Rémi, Bosinger, Steven E., Harper, Justin L., He, Tianyu, Paganini, Sara, Easley, Kirk A., Chahroudi, Ann, Benne, Clarisse, Gumber, Sanjeev, McGary, Colleen S., Rogers, Kenneth A., Deleage, Claire, Lucero, Carissa, Byrareddy, Siddappa N., Apetrei, Cristian, Estes, Jacob D., Lifson, Jeffrey D., Piatak, Michael, Chomont, Nicolas, Villinger, Francois, Silvestri, Guido, Brenchley, Jason M., Paiardini, Mirko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665780/
https://ncbi.nlm.nih.gov/pubmed/26551680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81400
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