Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques

In HIV/SIV-infected humans and rhesus macaques (RMs), a severe depletion of intestinal CD4(+) T-cells producing interleukin IL-17 and IL-22 associates with loss of mucosal integrity and chronic immune activation. However, little is known about the function of IL-17 and IL-22 producing cells during l...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Ryan, Emily S., Micci, Luca, Fromentin, Rémi, Paganini, Sara, McGary, Colleen S., Easley, Kirk, Chomont, Nicolas, Paiardini, Mirko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735119/
https://ncbi.nlm.nih.gov/pubmed/26829644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005412
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