Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

In pathogenic HIV and SIV infections of humans and rhesus macaques (RMs), preferential depletion of CD4(+) Th17 cells correlates with mucosal immune dysfunction and disease progression. Interleukin (IL)-21 promotes differentiation of Th17 cells, long-term maintenance of functional CD8(+) T cells, an...

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Autores principales: Pallikkuth, Suresh, Micci, Luca, Ende, Zachary S., Iriele, Robin I., Cervasi, Barbara, Lawson, Benton, McGary, Colleen S., Rogers, Kenneth A., Else, James G., Silvestri, Guido, Easley, Kirk, Estes, Jacob D., Villinger, Francois, Pahwa, Savita, Paiardini, Mirko
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701718/
https://ncbi.nlm.nih.gov/pubmed/23853592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003471
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