Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

In pathogenic HIV and SIV infections of humans and rhesus macaques (RMs), preferential depletion of CD4(+) Th17 cells correlates with mucosal immune dysfunction and disease progression. Interleukin (IL)-21 promotes differentiation of Th17 cells, long-term maintenance of functional CD8(+) T cells, an...

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Main Authors: Pallikkuth, Suresh, Micci, Luca, Ende, Zachary S., Iriele, Robin I., Cervasi, Barbara, Lawson, Benton, McGary, Colleen S., Rogers, Kenneth A., Else, James G., Silvestri, Guido, Easley, Kirk, Estes, Jacob D., Villinger, Francois, Pahwa, Savita, Paiardini, Mirko
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701718/
https://ncbi.nlm.nih.gov/pubmed/23853592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003471
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