Paucity of IL-21–producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques

IL-21 regulates Th17 cell homeostasis, enhances the differentiation of memory B cells and antibody-secreting plasma cells, and promotes the maintenance of CD8(+) T-cell responses. In this study, we investigated the phenotype, function, and frequency of blood and intestinal IL-21–producing cells in n...

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Detalhes bibliográficos
Main Authors: Micci, Luca, Cervasi, Barbara, Ende, Zachary S., Iriele, Robin I., Reyes-Aviles, Elane, Vinton, Carol, Else, James, Silvestri, Guido, Ansari, Aftab A., Villinger, Francois, Pahwa, Savita, Estes, Jacob D., Brenchley, Jason M., Paiardini, Mirko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496953/
https://ncbi.nlm.nih.gov/pubmed/22990011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-420240
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