Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells i...

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Pubblicato in:PLoS Pathog
Autori principali: Pino, Maria, Paganini, Sara, Deleage, Claire, Padhan, Kartika, Harper, Justin L., King, Colin T., Micci, Luca, Cervasi, Barbara, Mudd, Joseph C., Gill, Kiran P., Jean, Sherrie M., Easley, Kirk, Silvestri, Guido, Estes, Jacob D., Petrovas, Constantinos, Lederman, Michael M., Paiardini, Mirko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834281/
https://ncbi.nlm.nih.gov/pubmed/31626660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008081
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