Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells i...

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Publicado en:PLoS Pathog
Main Authors: Pino, Maria, Paganini, Sara, Deleage, Claire, Padhan, Kartika, Harper, Justin L., King, Colin T., Micci, Luca, Cervasi, Barbara, Mudd, Joseph C., Gill, Kiran P., Jean, Sherrie M., Easley, Kirk, Silvestri, Guido, Estes, Jacob D., Petrovas, Constantinos, Lederman, Michael M., Paiardini, Mirko
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834281/
https://ncbi.nlm.nih.gov/pubmed/31626660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008081
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