Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Rhesus cytomegalovirus (RhCMV)-based vaccines maintain effector-memory T cell responses (T(EM)) that protect ~50% of rhesus monkeys (RMs) challenged with simian immunodeficiency virus (SIV). Because human CMV (HCMV) causes disease in immune-deficient subjects, clinical translation will depend upon a...

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Vydáno v:Sci Transl Med
Hlavní autoři: Marshall, Emily E., Malouli, Daniel, Hansen, Scott G., Gilbride, Roxanne M., Hughes, Colette M., Ventura, Abigail B., Ainslie, Emily, Selseth, Andrea N., Ford, Julia C., Burke, David, Kreklywich, Craig N., Womack, Jennie, Legasse, Alfred W., Axthelm, Michael K., Kahl, Christoph, Streblow, Daniel, Edlefsen, Paul T., Picker, Louis J., Früh, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830438/
https://ncbi.nlm.nih.gov/pubmed/31316006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2603
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