Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Rhesus cytomegalovirus (RhCMV)-based vaccines maintain effector-memory T cell responses (T(EM)) that protect ~50% of rhesus monkeys (RMs) challenged with simian immunodeficiency virus (SIV). Because human CMV (HCMV) causes disease in immune-deficient subjects, clinical translation will depend upon a...

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Publicado no:Sci Transl Med
Main Authors: Marshall, Emily E., Malouli, Daniel, Hansen, Scott G., Gilbride, Roxanne M., Hughes, Colette M., Ventura, Abigail B., Ainslie, Emily, Selseth, Andrea N., Ford, Julia C., Burke, David, Kreklywich, Craig N., Womack, Jennie, Legasse, Alfred W., Axthelm, Michael K., Kahl, Christoph, Streblow, Daniel, Edlefsen, Paul T., Picker, Louis J., Früh, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830438/
https://ncbi.nlm.nih.gov/pubmed/31316006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2603
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