Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Rhesus cytomegalovirus (RhCMV)-based vaccines maintain effector-memory T cell responses (T(EM)) that protect ~50% of rhesus monkeys (RMs) challenged with simian immunodeficiency virus (SIV). Because human CMV (HCMV) causes disease in immune-deficient subjects, clinical translation will depend upon a...

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Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Marshall, Emily E., Malouli, Daniel, Hansen, Scott G., Gilbride, Roxanne M., Hughes, Colette M., Ventura, Abigail B., Ainslie, Emily, Selseth, Andrea N., Ford, Julia C., Burke, David, Kreklywich, Craig N., Womack, Jennie, Legasse, Alfred W., Axthelm, Michael K., Kahl, Christoph, Streblow, Daniel, Edlefsen, Paul T., Picker, Louis J., Früh, Klaus
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830438/
https://ncbi.nlm.nih.gov/pubmed/31316006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2603
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