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Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Rhesus cytomegalovirus (RhCMV)-based vaccines maintain effector-memory T cell responses (T(EM)) that protect ~50% of rhesus monkeys (RMs) challenged with simian immunodeficiency virus (SIV). Because human CMV (HCMV) causes disease in immune-deficient subjects, clinical translation will depend upon a...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Marshall, Emily E., Malouli, Daniel, Hansen, Scott G., Gilbride, Roxanne M., Hughes, Colette M., Ventura, Abigail B., Ainslie, Emily, Selseth, Andrea N., Ford, Julia C., Burke, David, Kreklywich, Craig N., Womack, Jennie, Legasse, Alfred W., Axthelm, Michael K., Kahl, Christoph, Streblow, Daniel, Edlefsen, Paul T., Picker, Louis J., Früh, Klaus
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830438/
https://ncbi.nlm.nih.gov/pubmed/31316006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2603
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