Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

The natural killer cell receptor NKG2D activates NK cells by engaging one of several ligands (NKG2DLs) belonging to either the MIC or ULBP families. Human cytomegalovirus (HCMV) UL16 and UL142 counteract this activation by retaining NKG2DLs and US18 and US20 act via lysomal degradation but the impor...

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Pubblicato in:PLoS Pathog
Autori principali: Sturgill, Elizabeth R., Malouli, Daniel, Hansen, Scott G., Burwitz, Benjamin J., Seo, Seongkyung, Schneider, Christine L., Womack, Jennie L., Verweij, Marieke C., Ventura, Abigail B., Bhusari, Amruta, Jeffries, Krystal M., Legasse, Alfred W., Axthelm, Michael K., Hudson, Amy W., Sacha, Jonah B., Picker, Louis J., Früh, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006984/
https://ncbi.nlm.nih.gov/pubmed/27580123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005868
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