CYTOMEGALOVIRUS VECTORS VIOLATE CD8+ T CELL EPITOPE RECOGNITION PARADIGMS

CD8+ T cell responses focus on a small fraction of pathogen- or vaccine-encoded peptides, and for some pathogens, these restricted recognition hierarchies limit the effectiveness of anti-pathogen immunity. We found that simian immunodeficiency virus (SIV) protein-expressing Rhesus Cytomegalovirus (R...

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Hoofdauteurs: Hansen, Scott G., Sacha, Jonah B., Hughes, Colette M., Ford, Julia C., Burwitz, Benjamin J., Scholz, Isabel, Gilbride, Roxanne M., Lewis, Matthew S., Gilliam, Awbrey N., Ventura, Abigail B., Malouli, Daniel, Xu, Guangwu, Richards, Rebecca, Whizin, Nathan, Reed, Jason S., Hammond, Katherine B., Fischer, Miranda, Turner, John M., Legasse, Alfred W., Axthelm, Michael K., Edlefsen, Paul T., Nelson, Jay A., Lifson, Jeffrey D., Früh, Klaus, Picker, Louis J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816976/
https://ncbi.nlm.nih.gov/pubmed/23704576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1237874
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