Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Tuberous sclerosis complex (TSC) is characterized by tumor development in the brain, heart, kidney, and lungs. In TSC tumors, loss of the TSC1/TSC2 protein complex leads to activation of mTORC1 with downstream effects on anabolism and cell growth. Because mTORC1 activation enhances mRNA transcriptio...

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Vydáno v:J Exp Med
Hlavní autoři: Zarei, Mahsa, Du, Heng, Nassar, Amin H., Yan, Rachel E., Giannikou, Krinio, Johnson, Sneha H., Lam, Hilaire C., Henske, Elizabeth P., Wang, Yubao, Zhang, Tinghu, Asara, John, Kwiatkowski, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829598/
https://ncbi.nlm.nih.gov/pubmed/31506280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190251
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