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TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β
Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by germline inactivating mutations of TSC1 or TSC2. In TSC-associated tumors of the brain, heart, skin, kidney and lung, inactivation of both alleles of TSC1 or TSC2 leads to hyperactivation of the mTORC1 pathway. The TSC/mTORC...
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| Udgivet i: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5905583/ https://ncbi.nlm.nih.gov/pubmed/29509898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy073 |
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