TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β

Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by germline inactivating mutations of TSC1 or TSC2. In TSC-associated tumors of the brain, heart, skin, kidney and lung, inactivation of both alleles of TSC1 or TSC2 leads to hyperactivation of the mTORC1 pathway. The TSC/mTORC...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Ogórek, Barbara, Lam, Hilaire C, Khabibullin, Damir, Liu, Heng-Jia, Nijmeh, Julie, Triboulet, Robinson, Kwiatkowski, David J, Gregory, Richard I, Henske, Elizabeth P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905583/
https://ncbi.nlm.nih.gov/pubmed/29509898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy073
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