TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, resulting in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1). Transcription factor EB (TFEB), a master regulator of lysosome biogenesis, is negatively regulated by mTORC1 through a RAG GTPase-dependent ph...

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Pubblicato in:Nat Commun
Autori principali: Alesi, Nicola, Akl, Elie W., Khabibullin, Damir, Liu, Heng-Jia, Nidhiry, Anna S., Garner, Emma R., Filippakis, Harilaos, Lam, Hilaire C., Shi, Wei, Viswanathan, Srinivas R., Morroni, Manrico, Ferguson, Shawn M., Henske, Elizabeth P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8275687/
https://ncbi.nlm.nih.gov/pubmed/34253722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24499-6
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