TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC(S75Y) Cardiomyopathy

A de novo missense variant in Rag GTPase protein C (RagC(S75Y)) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its pathogenicity and the related therapeutic strategy remain unclear. We generated a zebrafish Rragc(S56Y) (corresponding to human RagC(S75Y)) knock-...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Kim, Maengjo, Lu, Linghui, Dvornikov, Alexey V., Ma, Xiao, Ding, Yonghe, Zhu, Ping, Olson, Timothy M., Lin, Xueying, Xu, Xiaolei
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197163/
https://ncbi.nlm.nih.gov/pubmed/34071043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115494
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker