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Loss of FLCN inhibits canonical WNT signaling via TFE3

Lower lobe predominant pulmonary cysts occur in up to 90% of patients with Birt–Hogg–Dubé (BHD) syndrome, but the key pathologic cell type and signaling events driving this distinct phenotype remain elusive. Through examination of the LungMAP database, we found that folliculin (FLCN) is highly expre...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Mol Genet
Prif Awduron: Kennedy, John C, Khabibullin, Damir, Hougard, Thomas, Nijmeh, Julie, Shi, Wei, Henske, Elizabeth P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859437/
https://ncbi.nlm.nih.gov/pubmed/31272105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz158
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