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Loss of FLCN inhibits canonical WNT signaling via TFE3

Lower lobe predominant pulmonary cysts occur in up to 90% of patients with Birt–Hogg–Dubé (BHD) syndrome, but the key pathologic cell type and signaling events driving this distinct phenotype remain elusive. Through examination of the LungMAP database, we found that folliculin (FLCN) is highly expre...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Kennedy, John C, Khabibullin, Damir, Hougard, Thomas, Nijmeh, Julie, Shi, Wei, Henske, Elizabeth P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859437/
https://ncbi.nlm.nih.gov/pubmed/31272105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz158
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