Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Tuberous sclerosis complex (TSC) is characterized by tumor development in the brain, heart, kidney, and lungs. In TSC tumors, loss of the TSC1/TSC2 protein complex leads to activation of mTORC1 with downstream effects on anabolism and cell growth. Because mTORC1 activation enhances mRNA transcriptio...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Zarei, Mahsa, Du, Heng, Nassar, Amin H., Yan, Rachel E., Giannikou, Krinio, Johnson, Sneha H., Lam, Hilaire C., Henske, Elizabeth P., Wang, Yubao, Zhang, Tinghu, Asara, John, Kwiatkowski, David J.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829598/
https://ncbi.nlm.nih.gov/pubmed/31506280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190251
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