MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by tumor development in multiple organs, including renal angiomyolipoma. Biallelic loss of TSC1 or TSC2 is a known genetic driver of angiomyolipoma development, however whether an altered transcription...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zarei, Mahsa, Giannikou, Krinio, Du, Heng, Liu, Heng-Jia, Duarte, Melissa, Johnson, Sneha, Nassar, Amin H., Widlund, Hans R., Henske, Elizabeth P., Long, Henry W., Kwiatkowski, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796905/
https://ncbi.nlm.nih.gov/pubmed/33082558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01504-8
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