Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline

Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely unknown. In this work, we show that p38MAPK activity increases in neurons with age. By using mice expressing p38α‐lox and CamkII‐Cre alleles (p38α∆...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Aging Cell
मुख्य लेखकों: Moreno‐Cugnon, Leire, Revuelta, Miren, Arrizabalaga, Olatz, Colie, Sandra, Moreno‐Valladares, Manuel, Jimenez‐Blasco, Daniel, Gil‐Bea, Francisco, Llarena, Irantzu, Bolaños, Juan Pedro, Nebreda, Angel R., Matheu, Ander
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2019
विषय:
Original Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826142/
https://ncbi.nlm.nih.gov/pubmed/31560167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13044
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