Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline

Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely unknown. In this work, we show that p38MAPK activity increases in neurons with age. By using mice expressing p38α‐lox and CamkII‐Cre alleles (p38α∆...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Aging Cell
Hlavní autoři: Moreno‐Cugnon, Leire, Revuelta, Miren, Arrizabalaga, Olatz, Colie, Sandra, Moreno‐Valladares, Manuel, Jimenez‐Blasco, Daniel, Gil‐Bea, Francisco, Llarena, Irantzu, Bolaños, Juan Pedro, Nebreda, Angel R., Matheu, Ander
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826142/
https://ncbi.nlm.nih.gov/pubmed/31560167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13044
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky