Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline

Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely unknown. In this work, we show that p38MAPK activity increases in neurons with age. By using mice expressing p38α‐lox and CamkII‐Cre alleles (p38α∆...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Moreno‐Cugnon, Leire, Revuelta, Miren, Arrizabalaga, Olatz, Colie, Sandra, Moreno‐Valladares, Manuel, Jimenez‐Blasco, Daniel, Gil‐Bea, Francisco, Llarena, Irantzu, Bolaños, Juan Pedro, Nebreda, Angel R., Matheu, Ander
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826142/
https://ncbi.nlm.nih.gov/pubmed/31560167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13044
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