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Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline
The impairment of the activity of the brain is a major feature of aging, which coincides with a decrease in the function of neural stem cells. We have previously shown that an extra copy of regulated Ink4/Arf and p53 activity, in s-Ink4/Arf/p53 mice, elongates lifespan and delays aging. In this work...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4531087/ https://ncbi.nlm.nih.gov/pubmed/25990896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12343 |
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