mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

Background: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and glioma treatment remain unclear. Methods: SOX2 and SOX9 levels were examined in human biopsies. Gain and loss of function dete...

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Detalhes bibliográficos
Publicado no:Expert Opin Ther Targets
Main Authors: Garros-Regulez, Laura, Aldaz, Paula, Arrizabalaga, Olatz, Moncho-Amor, Veronica, Carrasco-Garcia, Estefania, Manterola, Lorea, Moreno-Cugnon, Leire, Barrena, Cristina, Villanua, Jorge, Ruiz, Irune, Pollard, Steven, Lovell-Badge, Robin, Sampron, Nicolas, Garcia, Idoia, Matheu, Ander
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898154/
https://ncbi.nlm.nih.gov/pubmed/26878385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2016.1151002
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