CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma

SIMPLE SUMMARY: Understanding how SOX2, a major driver of cancer stem cells, is regulated in cancer cells is relevant to tackle tumorigenesis. In this study, we deleted the SRR2 regulatory region in glioblastoma cells. Our data confirm that the SRR2 enhancer regulates SOX2 expression in cancer and r...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Saenz-Antoñanzas, Ander, Moncho-Amor, Veronica, Auzmendi-Iriarte, Jaione, Elua-Pinin, Alejandro, Rizzoti, Karine, Lovell-Badge, Robin, Matheu, Ander
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037847/
https://ncbi.nlm.nih.gov/pubmed/33805518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071574
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