CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma

SIMPLE SUMMARY: Understanding how SOX2, a major driver of cancer stem cells, is regulated in cancer cells is relevant to tackle tumorigenesis. In this study, we deleted the SRR2 regulatory region in glioblastoma cells. Our data confirm that the SRR2 enhancer regulates SOX2 expression in cancer and r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Saenz-Antoñanzas, Ander, Moncho-Amor, Veronica, Auzmendi-Iriarte, Jaione, Elua-Pinin, Alejandro, Rizzoti, Karine, Lovell-Badge, Robin, Matheu, Ander
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037847/
https://ncbi.nlm.nih.gov/pubmed/33805518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071574
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge