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Increased Arf/p53 activity in stem cells, aging and cancer

Arf/p53 pathway protects the cells against DNA damage induced by acute stress. This characteristic is the responsible for its tumor suppressor activity. Moreover, it regulates the chronic type of stress associated with aging. This is the basis of its anti‐aging activity. Indeed, increased gene dosag...

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Publicat a:Aging Cell
Autors principals: Carrasco‐Garcia, Estefania, Moreno, Manuel, Moreno‐Cugnon, Leire, Matheu, Ander
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334536/
https://ncbi.nlm.nih.gov/pubmed/28101907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12574
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