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Increased Arf/p53 activity in stem cells, aging and cancer

Arf/p53 pathway protects the cells against DNA damage induced by acute stress. This characteristic is the responsible for its tumor suppressor activity. Moreover, it regulates the chronic type of stress associated with aging. This is the basis of its anti‐aging activity. Indeed, increased gene dosag...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Aging Cell
Hauptverfasser: Carrasco‐Garcia, Estefania, Moreno, Manuel, Moreno‐Cugnon, Leire, Matheu, Ander
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334536/
https://ncbi.nlm.nih.gov/pubmed/28101907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12574
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