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Increased Arf/p53 activity in stem cells, aging and cancer
Arf/p53 pathway protects the cells against DNA damage induced by acute stress. This characteristic is the responsible for its tumor suppressor activity. Moreover, it regulates the chronic type of stress associated with aging. This is the basis of its anti‐aging activity. Indeed, increased gene dosag...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5334536/ https://ncbi.nlm.nih.gov/pubmed/28101907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12574 |
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